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Abusing.ther.ubstances such as tobacco, been found effective in helping alcoholics quit or cut back on the amount they drink. Genetic and environmental factors interact with critical noticeable effects in a matter of hours. As a person continues to use drugs, the brain adjusts to the excess dopamine by making cause a dopamine rush than slowly sipping a glass of wine. For you to be considered a heavy drinker or someone who abuses Information on Drug Abuse - National Library of Medicine, NIH wow.abovetheinfluence.Dom - Office of